The 2019 International Cellular Senescence Association (ICSA) conference was held in Athens, Sept 9-12, at the Biomedical Research Foundation of the Academy of Athens. The conference entitled “Cellular Senescence: the bright and dark side” attracted more than two hundred and fifty scientists from all over the world. Subjects presented at the conference covered a wide range of disciplines, providing a comprehensive overview of senescence. The organizing committee consisted of Prof Vassilis G Gorgoulis, Valery Krizhanovsky, Dr Dimitris Kletas and Associate Professor Konstantinos Evangelou.