Objective 5 and Deliverables of WP5
Α Cdc6 construct [CAG-loxP-eGFP-STOP-loxp-Cdc6-IRES-βGal (CAG-Cdc6)] was injected in zygote pronuclei. Following implantation in pseudopregnant females resulted in generation of the first known CAG-Cdc6 founders. Currently, these founders are undergoing crossings with C57BL/6J mice to obtain the CAG-Cdc6 mouse model. These mice will be crossed with whole body or tissue specific Cre animals to obtain corresponding Cdc6 overexpressing animal models.
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Prof. Vassilis G. Gorgoulis Laboratory of Histology-Embryology
Chair of Clinical Molecular Pathology, Ninewells Hospital and School of Medicine
University of Dundee, Dundee, UK
Biomedical Research Foundation of the Academy of Athens
Faculty Institute for Cancer Sciences, University of Manchester, Manchester Centre for Cellular Metabolism,
EMBO member
European Academy
Academia Europaea member
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